تاثیر کنترل گلایسمیک و مدت ابتلا به بیماری دیابت بر تغییر پذیری ضربان قلب(HRV) در مردان دیابتی مبتلا به نوروپاتی محیطی

Background & Aims: Type 2 diabetes is commonly associated with autonomic neuropathy. The aim of the present study was investigated the impact of glycemic control and disease duration (DD) on autonomic nervous function in Type-2 Diabetic Neuropathy Men by analysis of their heart rate variability (HRV). Materials & Methods:&nbsp; fifty-three Man with diabetes and peripheral neuropathy were recruited and categorized into four groups by HbA1c of 7% and DD of 10 years: group I (n = 16, HbA1c < 7%, DD < 10 years), group II (n = 13, HbA1c <&nbsp; 7%, DD &ge; 10 years), group III (n = 10, HbA1c &ge; 7 %, DD < 10 years), and group IV (n = 14, HbA1c &ge; 7 %, DD &ge; 10 years). HRV parameters as determined by separate frequency domain components (low frequency: LF, 0.04&ndash;0.15 Hz; high frequency: HF, 0.15&ndash;0.5 Hz; very low frequency: VLF, 0.0033&ndash;0.04 Hz; total power: TP, 0.04&ndash;0.5 Hz) were measured at rest. Two-way analysis of variance were used for statistical analysis and Hochbergs Post hoc test were used for determination place differences couple.&nbsp; Results: The main effect of HbA1c, DD and their interactions effect were significant with TP and VLF. While only the main effect of DD were significant with LF and HF. Hochbergs Post hoc test results for determination place differences couple showed that between TP and VLF were different according to HbA1c and DD. So that mean of TP and VLF significantly was higher in group I (HbA1c < 7%, DD < 10 years) than II, III and IV groups. Conclusion: These findings suggest that disease duration (DD) and early and intensive care in glycemic control is a key factor for preventing the occurrence of CAN in Type-2 Diabetic Neuropathy Men.